The Purdue Boilermakers return to the football field in 2021 for a complete season including nine Big Ten games and the return of Notre Dame to the schedule.
| Date | Time | At | Opponent | Location | TV | Result |
|---|---|---|---|---|---|---|
| Sep 4 | 7 PM | Home | Oregon State | West Lafayette, Ind. (ROSS-ADE STADIUM) |
FS1 | |
| Sep 11 | 3 PM | Away | UConn | Hartford, Conn. | CBS SN | |
| Sep 18 | 2:30 PM | Away | Notre Dame | South Bend, Ind. | NBC | |
| Sep 25 | TBD | Home | Illinois | West Lafayette, Ind. (ROSS-ADE STADIUM) |
||
| Oct 2 | Noon | Home | Minnesota | West Lafayette, Ind. (ROSS-ADE STADIUM) |
TBA | |
| Oct 16 | 3:30 PM | Away | Iowa | Iowa City, Iowa | TBA | |
| Oct 23 | TBD | Home | Wisconsin | West Lafayette, Ind. (ROSS-ADE STADIUM) |
||
| Oct 30 | TBD | Away | Nebraska | Lincoln, Neb. | ||
| Nov 6 | TBD | Home | Michigan State | West Lafayette, Ind. (ROSS-ADE STADIUM) |
||
| Nov 13 | TBD | Away | Ohio State | Columbus, Ohio | ||
| Nov 20 | TBD | Away | Northwestern | Chicago, Ill. (Wrigley Field) |
||
| Nov 27 | TBD | Home | Indiana | West Lafayette, Ind. (ROSS-ADE STADIUM) |